Apple privacy restrictions on more recent operating systems require administrators to grant permissions for full disk access on their Mac computers. Without this access, CrashPlan cannot back up some profile folders like Desktop, Documents, and Downloads. If the user grants full disk access permissions manually, it is possible that major operating system updates can undo these settings.
This article explains how to properly set these permissions. All screen shots in this article are from a Mac running macOS Sequoia (15).
Instructions
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Navigate to your Mac's System Settings.
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Scroll to find the Privacy & Security tab and click it.
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Click on Full Disk Access.

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Find CrashPlan in the list and make sure it is toggled on.

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If toggling on, you will be prompted for your Mac's credentials to allow the change. CrashPlan will then prompt to quit and reopen in order to process the change.
More information
Please open a ticket with the Help Desk if you have additional questions.